In 2000, a small group of individuals came together to form a not-for-profit, membership-supported organization called Nebraskans for Research (NFR). The purpose of the group was to provide a positive voice in support of the continued development of medical research and stem cell research in Nebraska.

In 2007, philanthropist Richard “Dick” Holland helped form the Nebraska Coalition, combining a group of business, education and community leaders with the members of Nebraskans for Research and taking the name Nebraska Coalition for Lifesaving Cures.

During the lifetime of both organizations members have worked hard to fend off efforts in both the state legislature as well as the University of Nebraska Board of Regents to endanger the freedom of research in Nebraska.